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The large multicentre CURPAP studyalso aimed to answer this question (Sandri et al.2008) and the presented results show that therewere no differences between groups in the needfor mechanical ventilation, or for the combinedoutcome of death or BPD (Sandri et al. Neu-trophils leave the blood randomly—that is, a given neutrophilmay circulate for only a few minutes or as long as 16 hoursbefore entering the perivascular connective tissue (a measuredhalf-life ofcirculatinghuman neutrophils isonly8 to 12hours).Neutrophils live for 1to2 days in the connectivetissue, afterwhich they are destroyed by apoptosis and are subsequentlyengulfed by macrophages. It ison these points where lowered resistance can be measured with electronicinstruments, such as Andy’s point finder; it is also where therapeutic pro-cedures are performed and diagnostic clues are obtained. For this reason, thenurse needs to look for clusters of signs and symptoms thatmay indicate changes in hydration status

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